![]() ![]() These morphogens provide positional information by promoting specific transcription factor profiles in each progenitor domain. This DV patterning results from a ventral-to-dorsal gradient of Sonic Hedgehog (Shh), which is complemented by bone morphogenetic proteins (BMPs) and Wnts acting in the dorsal neural tube. The vertebrate neural tube is patterned along the dorsoventral (DV) axis to form different progenitor domains, identified by unique patterns of transcription factor expression and distinct neuronal fates.
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